HYDROGEN THERAPY RESEARCH
Bone
Li, J., et al., Protective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis. BMC Musculoskelet Disord, 2017. 18(1): p. 58.
Guo, J., et al., Hydrogen-rich saline prevents bone loss in diabetic rats induced by streptozotocin. Int Orthop, 2017. 41(10): p. 2119-2128.
Yamada, T., et al., Hydrogen supplementation of preservation solution improves viability of osteochondral grafts. ScientificWorldJournal, 2014. 2014: p. 109876.
Wan, W.L., et al., An In Situ Depot for Continuous Evolution of Gaseous H2 Mediated by a Magnesium Passivation/Activation Cycle for Treating Osteoarthritis. Angew Chem Int Ed Engl, 2018.
Ostojic, S.M., et al., Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries. Postgrad Med, 2014. 126(5): p. 187-95.
Sun, Y., et al., Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats. Osteoporos Int, 2013. 24(3): p. 969-78.
Li, D.Z., et al., Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells. J Bone Miner Metab, 2013.
Guo, J.D., et al., Hydrogen water consumption prevents osteopenia in ovariectomized rats. Br J Pharmacol, 2013. 168(6): p. 1412-20.
Cai, W.W., et al., Treatment with hydrogen molecule alleviates TNFalpha-induced cell injury in osteoblast. Mol Cell Biochem, 2013. 373(1-2): p. 1-9.
Xu, Z., et al., Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema. J Inflamm (Lond), 2012. 9: p. 2.
Takeuchi, S., et al., Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study. Internal Medicine, 2012. 51(11): p. 1309-13.
Lekic, T., et al., Protective effect of hydrogen gas therapy after germinal matrix hemorrhage in neonatal rats.. Acta Neurochir Suppl, 2011. 111: p. 237-41.
Kubota, M., et al., Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Investigative Ophthalmology and Visual Science, 2011. 52(1): p. 427-33.
Itoh, T., et al., Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages. Biochemical and Biophysical Research Communications, 2011. 411(1): p. 143-9.
Hanaoka, T., et al., Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide. Medical Gas Research, 2011. 1(1): p. 18.
Kawasaki, H., J.J. Guan, and K. Tamama, Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials. Biochemical and Biophysical Research Communications, 2010. 397(3): p. 608-613.
Brain
Yuan, J., et al., Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway. J Surg Res, 2018. 228: p. 238-246.
Wu, X., et al., Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway. Brain Res, 2018.
Wang, H., et al., Hydrogen-Rich Saline Activated Autophagy via HIF-1alpha Pathways in Neuropathic Pain Model. Biomed Res Int, 2018. 2018: p. 4670834.
Varga, V., et al., Molecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs. Acta Pharmacol Sin, 2018.
Satoh, Y., et al., Molecular Hydrogen Prevents Social Deficits and Depression-Like Behaviors Induced by Low-Intensity Blast in Mice. J Neuropathol Exp Neurol, 2018.
Nishimaki, K., et al., Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment. Curr Alzheimer Res, 2018. 15(5): p. 482-492.
Jiang, X., et al., FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia. Behav Brain Res, 2018.
Imai, K., et al., Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model. Sci Rep, 2018. 8(1): p. 9221.
Huang, J.L., W.W. Liu, and X.J. Sun, Hydrogen inhalation improves mouse neurological outcomes after cerebral ischemia/reperfusion independent of anti-necroptosis. Med Gas Res, 2018. 8(1): p. 1-5.
Hou, C., et al., Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Abeta clearance. Free Radic Res, 2018: p. 1-12.
Choi, K.S., et al., Neuroprotective effects of hydrogen inhalation in an experimental rat intracerebral hemorrhage model. Brain Res Bull, 2018. 142: p. 122-128.
Ono, H., et al., Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection. J Stroke Cerebrovasc Dis, 2017.
Nishimaki, K., et al., Effects of molecular hydrogen assessed by an animal model and a
randomized clinical study on mild cognitive impairment. Curr Alzheimer Res, 2017.
Yoshii, Y., et al., Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice. Neurochem Res, 2017.
Yoneda, T., et al., Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet. Nutrients, 2017. 9(1).
Wen, D., et al., Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice. Neuropharmacology, 2017. 118: p. 199-208.
Shi, Y., et al., Hydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells signaling and proinflammatory cytokine release in neonatal rats. Neuroreport, 2017. 28(17): p. 1170-1175.
Murakami, Y., M. Ito, and I. Ohsawa, Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis. PLoS One, 2017. 12(5): p. e0176992.
Mizuno, K., et al., Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life. Med Gas Res, 2017. 7(4): p. 247-255.
Yoritaka, A., et al., Pilot study of H(2) therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial. Movement Disorders, 2013.
Matsuoka, T., et al., Hydrogen gas inhalation inhibits progression to the “irreversible” stage of shock after severe hemorrhage in rats. J Trauma Acute Care Surg, 2017.
Ma, H., et al., [Hydrogen-rich saline attenuates hyperalgesia and reduces cytokines in rats with post-herpetic neuralgia via activating autophagy]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2017. 33(2): p. 155-158.
Liu, Y., et al., Effect of hydrogen-rich water on the angiogenesis in lesion boundary brain tissue of traumatic brain injury-challenged rats. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2017. 10(3): p. 3807-3815.
Li, D. and Y. Ai, Hydrogen saline suppresses neuronal cell apoptosis and inhibits the p38 mitogenactivated protein kinasecaspase3 signaling pathway following cerebral ischemiareperfusion injury. Mol Med Rep, 2017. 16(4): p. 5321-5325.
Li, C., et al., Hydrogen-rich saline attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels. Am J Transl Res, 2017. 9(3): p. 1162-1172.
He, Y., et al., Image-guided hydrogen gas delivery for protection from myocardial ischemia-reperfusion injury via microbubbles. ACS Appl Mater Interfaces, 2017.
Gao, Q., et al., Molecular hydrogen increases resilience to stress in mice. Sci Rep, 2017. 7(1): p. 9625.
Zhao, M., et al., Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice. J Neuroimmunol, 2016. 294: p. 6-13.
Zhang, Y., et al., Effects of hydrogen-rich water on depressive-like behavior in mice. Sci Rep, 2016. 6: p. 23742.
Takaenoki, Y., et al., Neonatal exposure to sevoflurane in mice causes deficits in maternal behavior later in adulthood. Anesthesiology, 2014. 120(2): p. 403-15.
Yonamine, R., et al., Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice. Anesthesiology, 2013. 118(1): p. 105-13.
Zhang, Y., et al., Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis. Neurochem Res, 2016. 41(4): p. 770-8.
Zhang, L., et al., Hydrogen has a neuroprotective effect via activation of Nrf-2/HO-1 pathway in ischemia reperfusion rat. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016. 9(6): p. 10521-10528.
Yang, L., D. Li, and S. Chen, Hydrogen water reduces NSE, IL-6, and TNF-alpha levels in hypoxic-ischemic encephalopathy. Open Med (Wars), 2016. 11(1): p. 399-406.
Wang, X., et al., The protective effects of hydrogen on HO-1 expression in the brainafter focal cerebral ischemia reperfusion in rats. Turk J Med Sci, 2016. 46(5): p. 1534-1539.
Tian, R., et al., Hydrogen-rich water attenuates brain damage and inflammation after traumatic brain injury in rats. Brain Res, 2016. 1637: p. 1-13.
Shao, A., et al., Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-kappaB Pathway and NLRP3 Inflammasome. Mol Neurobiol, 2016. 53(5): p. 3462-3476.
Nemeth, J., et al., Molecular hydrogen affords neuroprotection in a translational piglet model of hypoxic-ischemic encephalopathy. J Physiol Pharmacol, 2016. 67(5): p. 677-689.
Li, Q., et al., Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia/Reperfusion Rats: Up-Regulated Tregs and Down-Regulated miR-21, miR-210 and NF-kappaB Expression. Neurochem Res, 2016. 41(10): p. 2655-2665.
Cui, J., et al., Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-reperfusion injury in rats – A possible new hydrogen resource for clinical use. Neuroscience, 2016. 335: p. 232-41.
Chen, X., et al., [Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rat with traumatic brain injury]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, 2016. 28(5): p. 460-4.
Bai, X., et al., Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice. Brain Res, 2016. 1646: p. 410-7.
Zhang, Y.G., et al., Hydrogen-rich saline promotes motor functional recovery following peripheral nerve autografting in rats. Experimental and Therapeutic Medicine., 2015. 10(2).
Yu, Y., et al., Protective effect of hydrogenrich medium against high glucoseinduced apoptosis of Schwann cells in vitro. Mol Med Rep, 2015. 12(3): p. 3986-92.
Wei, R., et al., Hydrogen Suppresses Hypoxia/Reoxygenation-Induced Cell Death in Hippocampal Neurons Through Reducing Oxidative Stress. Cell Physiol Biochem, 2015. 36(2): p. 585-98.
Takeuchi, S., et al., Hydrogen improves neurological function through attenuation of blood-brain barrier disruption in spontaneously hypertensive stroke-prone rats. BMC Neurosci, 2015. 16: p. 22.
Shao, A., et al., Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-kappaB Pathway and NLRP3 Inflammasome. Mol Neurobiol, 2015.
Nakano, T., et al., Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury. J Clin Biochem Nutr, 2015. 57(3): p. 178-82.
Lin, C.L., et al., Hydrogen-rich water attenuates amyloid beta-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells. Chem Biol Interact, 2015. 240: p. 12-21.
Han, L., et al., Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins. Brain Res, 2015.
Du, Z., et al., Three hydrogen-rich solutions protect against intestinal injury in uncontrolled hemorrhagic shock. Int J Clin Exp Med, 2015. 8(5): p. 7620-6.
Du, Z., et al., Effects of three hydrogen-rich liquids on hemorrhagic shock in rats. J Surg Res, 2015. 193(1): p. 377-82.
Chen, Y., et al., H2Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. Inflammation, 2015. 38(5): p. 1835-46.
Zhang, L., et al., Hydrogen-rich saline controls remifentanil-induced hypernociception and NMDA receptor NR1 subunit membrane trafficking through GSK-3beta in the DRG in rats. Brain Res Bull, 2014. 106C: p. 47-55.
Wang, T., et al., Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats. Toxicol Appl Pharmacol, 2014.
Tomura, S., et al., Physiological effects of combination therapy of intracisternal infusion of magnesium sulfate solution and intravenous injection of hydrogen-enriched fluid in the rat. Bōei Ika Daigakkō zasshi= Journal of the National Defense Medical College, 2014. 39: p. 96-102.
Mei, K., et al., Hydrogen protects rats from dermatitis caused by local radiation. J Dermatolog Treat, 2014. 25(2): p. 182-8.
Mano, Y., et al., Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion. Free Radic Biol Med, 2014. 69: p. 324-30.
Liu, L., et al., Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis. Brain Res, 2014. 1589: p. 78-92.
Liu, F.T., et al., Molecular Hydrogen Suppresses Reactive Astrogliosis Related to Oxidative Injury during Spinal Cord Injury in Rats. CNS Neurosci Ther, 2014.
Kashiwagi, T., et al., Electrochemically reduced water protects neural cells from oxidative damage. Oxid Med Cell Longev, 2014. 2014: p. 869121.
Hong, Y., et al., Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway. PLoS One, 2014. 9(4): p. e96212.
Dohi, K., et al., Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury. PLoS One, 2014. 9(9): p. e108034.
Cui, Y., et al., Hydrogen-rich saline attenuates neuronal ischemia-reperfusion injury by protecting mitochondrial function in rats. J Surg Res, 2014.
Zhuang, Z., et al., Nuclear factor-kappaB/Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on the brain following experimental subarachnoid hemorrhage in rabbits. J Neurosci Res, 2013. 91(12): p. 1599-608.
Shen, M.H., et al., Neuroprotective effect of hydrogen-rich saline in acute carbon monoxide poisoning. CNS Neurosci Ther, 2013. 19(5): p. 361-3.
Olah, O., et al., Delayed neurovascular dysfunction is alleviated by hydrogen in asphyxiated newborn pigs. Neonatology, 2013. 104(2): p. 79-86.
Nagatani, K., et al., Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies. Med Gas Res, 2013. 3: p. 13.
Matsumoto, A., et al., Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice. Sci Rep, 2013. 3: p. 3273.
Manaenko, A., et al., Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice. Critical Care Medicine, 2013. 41(5): p. 1266-75.
Huang, G., et al., The neuroprotective effects of intraperitoneal injection of hydrogen in rabbits with cardiac arrest. Resuscitation, 2013. 84(5): p. 690-5.
Feng, Y., et al., Hydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats. Curr Eye Res, 2013. 38(3): p. 396-404.
Zhuang, Z., et al., Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits. BMC Neurosci, 2012. 13: p. 47.
Zhou, J., et al., Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture. Journal of Surgical Research, 2012. 178(1): p. 390-400.
Zhan, Y., et al., Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats. Critical Care Medicine, 2012. 40(4): p. 1291-6.
Wang, W., et al., Hydrogen rich saline reduces immune-mediated brain injury in rats with acute carbon monoxide poisoning. Neurological Research, 2012. 34(10): p. 1007-15.
Spulber, S., et al., Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behaviour in mice. PLoS One, 2012. 7(7): p. e42078.
Ji, X., et al., Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress. Journal of Surgical Research, 2012. 178(1): p. e9-16.
Ito, M., et al., Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats. Med Gas Res, 2012. 2(1): p. 15.
Hou, Z., et al., Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury. Brain Res Bull, 2012. 88(6): p. 560-5.
Hong, Y., et al., Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid hemorrhage in rats. J Neurosci Res, 2012. 90(8): p. 1670-80.
Yan, H., et al., The neuroprotective effects of electrolyzed reduced water and its model water containing molecular hydrogen and Pt nanoparticles. BMC Proc, 2011. 5 Suppl 8: p. P69.
Wang, C., et al., Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-kappaB activation in a rat model of amyloid-beta-induced Alzheimer’s disease. Neuroscience Letters, 2011. 491(2): p. 127-32.
Ueda, Y., T. Kojima, and T. Oikawa, Hippocampal gene network analysis suggests that coral calcium hydride may reduce accelerated senescence in mice. Nutrition Research, 2011. 31(11): p. 863-72.
Sun, Q., et al., Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity. Critical Care Medicine, 2011. 39(4): p. 765-9.
Shen, L., et al., Hydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest. Neurochemical Research, 2011. 36(8): p. 1501-11.
Ono, H., et al., Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study. Medical Gas Research, 2011. 1(1): p. 12.
Manaenko, A., et al., Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral hemorrhage. Acta Neurochir Suppl, 2011. 111: p. 179-83.
Liu, W., et al., Protective effects of hydrogen on fetal brain injury during maternal hypoxia. Acta Neurochir Suppl, 2011. 111: p. 307-11.
Kuroki, C., et al., Neuroprotective effects of hydrogen gas on brain in three types of stress models: A P-31-NMR and ESR study. Neuroscience Research, 2011. 71: p. E406-E406.
Kobayashi, H., et al., Effects of Hydrogen Gas in a Mouse Cold Induced Brain Injury Model. Journal of Neurotrauma, 2011. 28(5): p. A64-A64.
Hugyecz, M., et al., Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. Brain Research, 2011. 1404: p. 31-8.
Eckermann, J.M., et al., Hydrogen is neuroprotective against surgically induced brain injury. Medical Gas Research, 2011. 1(1): p. 7.
Yokoi, I., Neuroprotective effects of hydrogen gas on brain in three types of stress models: a P-31 NMR and ESR study. Neuroscience Research, 2010. 68: p. E320-E320.
Ueda, Y., A. Nakajima, and T. Oikawa, Hydrogen-Related Enhancement of In Vivo Antioxidant Ability in the Brain of Rats Fed Coral Calcium Hydride. Neurochemical Research, 2010. 35(10): p. 1510-1515.
Li, J., et al., Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by reduction of oxidative stress. Brain Res, 2010. 1328: p. 152-161.
Ji, X., et al., Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. Brain Research, 2010. 1354: p. 196-205.
Hong, Y., S. Chen, and J.M. Zhang, [Research advances on hydrogen therapy in nervous system diseases]. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2010. 39(6): p. 638-43.
Gu, Y., et al., Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice. Journal of Clinical Biochemistry and Nutrition, 2010. 46(3): p. 269-276.
Domoki, F., et al., Hydrogen is Neuroprotective and Preserves Cerebrovascular Reactivity in Asphyxiated Newborn Pigs. Pediatric Research, 2010. 68(5): p. 387-392.
Bari, F., et al., Inhalation of Hydrogen Gas Protects Cerebrovascular Reactivity Against Moderate but Not Severe Perinatal Hypoxic Injury in Newborn Piglets. Stroke, 2010. 41(4): p. E323-E323.
Nagata, K., et al., Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice. Neuropsychopharmacology, 2009. 34(2): p. 501-508.
Kuroki, C., et al., Neuroprotective effects of hydrogen gas on brain in three types of stress models: alpha P-31-NMR study. Neuroscience Research, 2009. 65: p. S124-S124.
Fujita, K., et al., Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. PLoS One, 2009. 4(9): p. e7247.
Fu, Y., et al., Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease. Neuroscience Letters, 2009. 453: p. 81–85.
Sato, Y., et al., Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem Biophys Res Commun, 2008. 375(3): p. 346-350.
Kashiwagi, T., et al., Suppression of Oxidative Stress-Induced Apoptosis of Neuronal Cells by Electrolyzed-Reduced Water. Animal Cell Technology Meets Genomics, 2005. 2: p. 257-260.
Lungs and other Organs
Zhang, G., et al., The Anti-inflammatory Effect of Hydrogen on Lung Transplantation Model of Pulmonary Microvascular Endothelial Cells During Cold Storage Period. Transplantation, 2018. 102(8): p. 1253-1261.
Wu, D., et al., Hydrogen protects against hyperoxia-induced apoptosis in type II alveolar epithelial cells via activation of PI3K/Akt/Foxo3a signaling pathway. Biochem Biophys Res Commun, 2018. 495(2): p. 1620-1627.
Lu, W., et al., Hydrogen gas inhalation protects against cigarette smoke-induced COPD development in mice. J Thorac Dis, 2018. 10(6): p. 3232-3243.
Haam, S., et al., Hydrogen gas inhalation during ex vivo lung perfusion of donor lungs recovered after cardiac death. J Heart Lung Transplant, 2018.
Chen, M., et al., Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses. Sci Rep, 2018. 8(1): p. 8004.
Zhao, C., et al., Changes in IL-4 and IL-13 expression in allergic-rhinitis treated with hydrogen-rich saline in guinea-pig model. Allergol Immunopathol (Madr), 2017.
Yu, S., et al., Hydrogen-rich saline attenuates eosinophil activation in a guinea pig model of allergic rhinitis via reducing oxidative stress. J Inflamm (Lond), 2017. 14: p. 1.
Ying, Y., et al., Protective effect of hydrogen-saturated saline on acute lung injury induced by oleic acid in rats. J Orthop Surg Res, 2017. 12(1): p. 134.
Yan, W.M., et al., Effects of hydrogen-rich saline on endotoxin-induced uveitis. Med Gas Res, 2017. 7(1): p. 9-18.
Xiao, L. and N. Miwa, Hydrogen-rich water achieves cytoprotection from oxidative stress injury in human gingival fibroblasts in culture or 3D-tissue equivalents, and wound-healing promotion, together with ROS-scavenging and relief from glutathione diminishment. Hum Cell, 2017. 30(2): p. 72-87.
Wang, K., et al., Hydrogen-rich saline prevents the down regulation of claudin-5 protein in septic rat lung via the PI3K/Akt signaling pathway. Int J Clin Exp Med, 2017. 10(8): p. 11717-11727.
Takahashi, M., et al., Immersing lungs in hydrogen-rich saline attenuates lung ischaemia-reperfusion injury. Eur J Cardiothorac Surg, 2017. 51(3): p. 442-448.
Suzuki, Y., et al., Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice. Biochem Biophys Res Commun, 2017. 492(1): p. 74-81.
Liu, Z., et al., Effect of Hydrogen-Rich Saline on Postoperative Intra-Abdominal Adhesion Bands Formation in Mice. Med Sci Monit, 2017. 23: p. 5363-5373.
Liu, X., et al., Hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smoke-induced rat model. Int J Chron Obstruct Pulmon Dis, 2017. 12: p. 1309-1324.
Li, Q., Y. Tanaka, and N. Miwa, Influence of hydrogen-occluding-silica on migration and apoptosis in human esophageal cells in vitro. Med Gas Res, 2017. 7(2): p. 76-85.
Kim, J., H.J. Lee, and S.H. Hong, Inhibition of streptococcal biofilm by hydrogen water. J Dent, 2017. 58: p. 34-39.
He, Y., et al., Effects of Hydrogen Gas Inhalation on Endometriosis in Rats. Reprod Sci, 2017. 24(2): p. 324-331.
Ge, L., et al., Hydrogen-rich saline attenuates spinal cord hemisection-induced testicular injury in rats. Oncotarget, 2017. 8(26): p. 42314-42331.
Dong, W.W., et al., Protective Effects of Hydrogen-Rich Saline Against Lipopolysaccharide-Induced Alveolar Epithelial-to-Mesenchymal Transition and Pulmonary Fibrosis. Med Sci Monit, 2017. 23: p. 2357-2364.
Audi, S.H., et al., Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury can be Tracked in vivo Using Molecular Imaging. Shock, 2017. 48(4): p. 467-476.
Ushida, T., et al., Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model. Free Radic Biol Med, 2016. 101: p. 524-533.
Tao, B., et al., Effects of hydrogen-rich saline on aquaporin 1, 5 in septic rat lungs. J Surg Res, 2016. 202(2): p. 291-8.
Muramatsu, Y., et al., Hydrogen-rich water ameliorates bronchopulmonary dysplasia (BPD) in newborn rats. Pediatr Pulmonol, 2016. 51(9): p. 928-35.
Miyazaki, N., et al., Preventive Effect of Hydrogen Water on the Development of Detrusor Overactivity in a Rat Model of Bladder Outlet Obstruction. J Urol, 2016. 195(3): p. 780-7.
Meng, C., et al., Protection of donor lung inflation in the setting of cold ischemia against ischemia-reperfusion injury with carbon monoxide, hydrogen, or both in rats. Life Sci, 2016. 151: p. 199-206.
Huang, S.L., J. Jiao, and H.W. Yan, Hydrogen-rich saline attenuates steroid-associated femoral head necrosis through inhibition of oxidative stress in a rabbit model. Exp Ther Med, 2016. 11(1): p. 177-182.
Hong, Y., et al., Combination therapy of molecular hydrogen and hyperoxia improves survival rate and organ damage in a zymosan-induced generalized inflammation model. Exp Ther Med, 2016. 11(6): p. 2590-2596.
He, X., et al., Hydrogen-rich Water Exerting a Protective Effect on Ovarian Reserve Function in a Mouse Model of Immune Premature Ovarian Failure Induced by Zona Pellucida Chin Med J (Engl), 2016. 129(19): p. 2331-7.
Hara, F., et al., Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells. Circ J, 2016.
Diao, M., et al., Hydrogen Gas Inhalation Attenuates Seawater Instillation-Induced Acute Lung Injury via the Nrf2 Pathway in Rabbits. Inflammation, 2016.
Chen, S., W. Jiang, and X.H. Wang, Protective Effect of Hydrogen Injected Subcutaneously on Testicular Tissues of Rats Exposed to Cigarette Smoke. West Indian Med J, 2016.
Chen, L., et al., Re: Preventive Effect of Hydrogen Water on the Development of Detrusor Overactivity in a Rat Model of Bladder Outlet Obstruction: N. Miyazaki, O. Yamaguchi, M. Nomiya, K. Aikawa and J. Kimura J Urol 2016;195:780-787. J Urol, 2016. 196(2): p. 620-1.
Zhang, Y., Y. Liu, and J. Zhang, Saturated hydrogen saline attenuates endotoxin-induced lung dysfunction. J Surg Res, 2015. 198(1): p. 41-9.
Zhai, Y., et al., Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats. Exp Mol Pathol, 2015. 98(2): p. 268-276.
Yuan, L., et al., Administration of hydrogen-rich saline in mice with allogeneic hematopoietic stem-cell transplantation. Med Sci Monit, 2015. 21: p. 749-54.
Wu, Q., et al., Hydrogen water alleviates lung injury induced by one-lung ventilation. J Surg Res, 2015.
Sato, C., et al., Effects of hydrogen water on paraquat-induced pulmonary fibrosis in mice. The Kitasato medical journal 2015. 45(1): p. 9-16.
Nakata, K., et al., Stimulation of human damaged sperm motility with hydrogen molecule. Med Gas Res, 2015. 5(1): p. 2.
Liu, R., et al., Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats. Exp Biol Med (Maywood), 2015.
Liu, H., et al., Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury. Shock, 2015. 43(5): p. 504-11.
Kishimoto, Y., et al., Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects. J Thorac Cardiovasc Surg, 2015. 150(3): p. 645-654 e3.
Hattori, Y., et al., Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury. Free Radic Res, 2015. 49(8): p. 1026-37.
Haam, S., et al., The effects of hydrogen gas inhalation during ex vivo lung perfusion on donor lungs obtained after cardiac death. Eur J Cardiothorac Surg, 2015. 48(4): p. 542-7.
Guan, Z., et al., Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells. Arch Gynecol Obstet, 2015.
Chen, X., et al., Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury. Oxid Med Cell Longev, 2015. 2015: p. 106836.
Chen, S. and W. Jiang, Effect of hydrogen injected subcutaneously on testicular tissues of rats exposed to cigarette smoke. Int J Clin Exp Med, 2015. 8(4): p. 5565-70.
Zhang, J., et al., Effect of hydrogen-rich water on acute peritonitis of rat models. Int Immunopharmacol, 2014. 21(1): p. 94-101.
Tomofuji, T., et al., Effects of hydrogen-rich water on aging periodontal tissues in rats. Sci Rep, 2014. 4: p. 5534.
Noda, K., et al., Hydrogen Preconditioning During Ex Vivo Lung Perfusion Improves the Quality of Lung Grafts in Rats. Transplantation 2014.
Li, S., et al., Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice. J Assist Reprod Genet, 2014. 31(1): p. 109-14.
Du, Z., et al., Protective effects of hydrogen-rich saline in uncontrolled hemorrhagic shock. Journal of Surgical Research, 2014. In press.
Xiao, M., et al., Hydrogen-rich saline reduces airway remodeling via inactivation of NF-kappaB in a murine model of asthma. Eur Rev Med Pharmacol Sci, 2013. 17(8): p. 1033-43.
Ning, Y., et al., Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats. PLoS One, 2013. 8(12): p. e83429.
Liu, W., et al., Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury. World J Gastroenterol, 2013. 19(4): p. 492-502.
Kawamura, T., et al., Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol, 2013. 304(10): p. L646-56.
Xie, K., et al., Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis. Shock, 2012. 37(5): p. 548-55.
Tanaka, Y., et al., Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun, 2012. 425(4): p. 873-9.
Shi, J., et al., Hydrogen saline is protective for acute lung ischaemia/reperfusion injuries in rats. Heart Lung Circ, 2012. 21(9): p. 556-63.
Liang, C., et al., [Effect of hydrogen inhalation on p38 MAPK activation in rats with lipopolysaccharide- induced acute lung injury]. Nan Fang Yi Ke Da Xue Xue Bao, 2012. 32(8): p. 1211-3.
Terasaki, Y., et al., Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. American Journal of Physiology – Lung Cellular and Molecular Physiology, 2011. 301(4): p. L415-26.
Sun, Q.A., et al., Hydrogen-Rich Saline Provides Protection Against Hyperoxic Lung Injury. Journal of Surgical Research, 2011. 165(1): p. E43-E49.
Qiu, X., et al., Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol, 2011. 11(12): p. 2130-7.
Liu, S.L., et al., Hydrogen Therapy may be a Novel and Effective Treatment for COPD. Front Pharmacol, 2011. 2: p. 19.
Liu, S., et al., Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats. Journal of Biomedicine & Biotechnology, 2011. 2011: p. 305086.
Huang, C.S., et al., Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochemical and Biophysical Research Communications, 2011. 408(2): p. 253-8.
Fang, Y., et al., Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model. Journal of Burn Care and Research, 2011. 32(3): p. e82-91.
Zheng, J., et al., Saturated hydrogen saline protects the lung against oxygen toxicity. Undersea & Hyperbaric Medicine, 2010. 37(3): p. 185-192.
Qiu, X.C., et al., [Effect of hydrogen-rich saline on blood pressure and antioxidant ability of lung tissue in scalded rats following delayed resuscitation]. Zhonghua Shao Shang Za Zhi, 2010. 26(6): p. 435-8.
Huang, C.S., et al., Hydrogen inhalation ameliorates ventilator-induced lung injury. Critical Care, 2010. 14(6): p. R234.
Cancer
Yang, Y., Y. Zhu, and X. Xi, Anti‑inflammatory and antitumor action of hydrogen via reactive oxygen species. Oncology Letters, 2018. 16(3): p. 2771-2776.
Wang, D., et al., Hydrogen gas inhibits lung cancer progression through targeting SMC3. Biomed Pharmacother, 2018. 104: p. 788-797.
Jiang, Y., et al., Therapeutic efficacy of hydrogenrich saline alone and in combination with PI3K inhibitor in nonsmall cell lung cancer. Mol Med Rep, 2018. 18(2): p. 2182-2190.
Yang, Q., et al., Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy. Mol Clin Oncol, 2017. 7(5): p. 891-896.
Runtuwene, J., et al., Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer. PeerJ, 2015. 3: p. e859.
Chen, Y., et al., On the antitumor properties of biomedical magnesium metal. Journal of Materials Chemistry B, 2015. 3(5): p. 849-858.
Nan, M., C. Yangmei, and Y. Bangcheng, Magnesium metal-A potential biomaterial with antibone cancer properties. J Biomed Mater Res A, 2014. 102(8): p. 2644-51.
Motoishi, A., et al., Influence of Active Hydrogen Discharged from Palladium-Nickel Alloy Powder on Biological Cells. Advanced Materials Research, 2013. 669: p. 273-278.
Matsuzaki, M., et al., Mechanism of Cancer Cell Death Induced by Hydrogen Discharged from Palladium Base Hydrogen Storage Alloy, in Materials Science and Chemical Engineering p. 284-290.
Kinjo, T., et al., Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells. Cytotechnology, 2012. 64(3): p. 357-371.
Akio Kagawa, K.K., Masayuki Mizumoto, Yutaka Tagawa, Yoichi Masiko, Influence of Hydrogen Discharged from Palladium Base Hydrogen Storage Alloys on Cancer Cells. Materials Science Forum, 2012. 706: p. 520-525.
Matsushita, T., et al., Investigation of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging. Jpn J Radiol, 2011. 29(7): p. 503-12.
Kang, K.-M., et al., Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Medical Gas Research, 2011. 1: p. 11.
Nakanishi, K., et al., growth suppression of HL60 and L6 cells by atomic hydrogen, in Animal Cell Technology: Basic & Applied Aspects, . 2010, Springer Netherlands. p. 323-325.
Asada, R., et al., Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell death. Oncol Rep, 2010. 24(6): p. 1463-70.
Tsai, C.F., et al., Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells due to electrolyzed-reduced water and glutathione. Biosci Biotechnol Biochem, 2009. 73(2): p. 280-7.
Saitoh, Y., et al., Platinum nanocolloid-supplemented hydrogen dissolved water inhibits growth of human tongue carcinoma cells preferentially over normal cells. Exp Oncol, 2009. 31(3): p. 156-62.
Nakashima-Kamimura, N., et al., Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol, 2009.
Ye, J., et al., Inhibitory effect of electrolyzed reduced water on tumor angiogenesis. Biological & Pharmaceutical Bulletin, 2008. 31(1): p. 19-26.
Saitoh, Y., et al., Neutral pH Hydrogen-Enriched Electrolyzed Water Achieves Tumor-Preferential Clonal Growth Inhibition Over Normal Cells and Tumor Invasion Inhibition Concurrently With Intracellular Oxidant Repression. Oncology Research, 2008. 17(6): p. 247-255.
Nishikawa, H., et al., Suppression of two-stage cell transformation by electrolyzed reduced water containing platinum nanoparticles, in Animal Cell Technology: Basic & Applied Aspects. 2006, Springer Netherlands. p. 113-119.
Nishikawa, R., et al., Electrolyzed Reduced Water Supplemented with Platinum Nanoparticles Suppresses Promotion of Two-stage Cell Transformation. Cytotechnology, 2005. 47(1-3): p. 97-105.
Nishikawa, R., et al., Suppression of two-stage cell transformation by electrolyzed reduced water/platinum nanocolloids. In Vitro Cellular & Developmental Biology-Animal, 2004. 40: p. 79A-79A.
LEE, K.-J., et al., Anticancer Effect of Alkaline Reduced Water. J Int Soc Life Inf Sci, 2004. 22(2): p. 302-305.
Jun, Y., et al., Suppression of invasion of cancer cells and angiogenesis by electrolyzed reduced water. In Vitro Cellular & Developmental Biology-Animal, 2004. 40: p. 79A-79A.
Komatsu, T., Katakura, Y., Teruya, K., Otsubo, K., Morisawa, S., & and S. Shirahata, Electrolyzed reduced water induces differentiation in K-562 human leukemia cells. Animal cell technology: Basic & applied aspects, 2003: p. 387-391.
Shirahata, S.K., K. Kusumoto, M. Gotoh, K. Teruya, K. Otsubo, J. S. Morisawa, H. Hayashi, K. Katakura, Electrolyzed Reduced Water Which Can Scavenge Active Oxygen Species Supresses Cell Growth and Regulates Gene Expression of Animal Cells. New Developments and New Applications in Animal Cell Technology, 2002: p. 93-96.
Roberts, B.J., et al., Response of five established solid transplantable mouse tumors and one mouse leukemia to hyperbaric hydrogen. Cancer Treat Rep, 1978. 62(7): p. 1077-9.
Liver
Li, H., et al., Hydrogen-rich saline protects against small-scale liver ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress. Life Sci, 2018. 194: p. 7-14.
Ishikawa, T., et al., Post-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from donors after cardiac death: a preliminary study. Surg Today, 2018.
Chen, M., et al., Hydrogen protects against liver injury during CO2 pneumoperitoneum in rats. Oncotarget, 2018. 9(2): p. 2631-2645.
Zhai, X., et al., Hydrogen-rich saline improves nonalcoholic fatty liver disease by alleviating oxidative stress and activating hepatic PPARalpha and PPARgamma. Mol Med Rep, 2017. 15(3): p. 1305-1312.
Wang, D., et al., The protective role of hydrogen-rich saline against liver injury caused by acetaminophen in mice. Int J Clin Exp Med, 2017. 10(8): p. 11646-11654.
Uto, K., et al., Hydrogen Rich Solution Attenuates Cold Ischemia-Reperfusion Injury in Rat Liver Transplantation. Transplantation, 2017. 101(5S-3): p. S18.
Lin, C.P., et al., Anti-oxidant and anti-inflammatory effects of hydrogen-rich water alleviate ethanol-induced fatty liver in mice. World J Gastroenterol, 2017. 23(27): p. 4920-4934.
Li, H., et al., Inhalation of high concentrations of hydrogen ameliorates liver ischemia/reperfusion injury through A2A receptor mediated PI3K-Akt pathway. Biochem Pharmacol, 2017. 130: p. 83-92.
Iketani, M., et al., Preadministration of Hydrogen-Rich Water Protects Against Lipopolysaccharide-Induced Sepsis and Attenuates Liver Injury. Shock, 2017. 48(1): p. 85-93.
Golshahi, H., et al., Protective effect of intraportal infusion of hypothermic hydrogen-rich saline solution on hepatic warm ischemia/reperfusion injury in rat model. Brazilian Journal of Veterinary Pathology, 2017. 10(1): p. 10-21.
Shimada, S., et al., Hydrogen Gas Ameliorates Hepatic Reperfusion Injury After Prolonged Cold Preservation in Isolated Perfused Rat Liver. Artif Organs, 2016. 40(12): p. 1128-1136.
Shi, Q., et al., Hydrogen-Rich Saline Attenuates Acute Hepatic Injury in Acute Necrotizing Pancreatitis by Inhibiting Inflammation and Apoptosis, Involving JNK and p38 Mitogen-Activated Protein Kinase-dependent Reactive Oxygen Species. Pancreas, 2016. 45(10): p. 1424-1431.
Liu, Q., et al., Hydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with obstructive jaundice. Mol Med Rep, 2016. 13(4): p. 3588-96.
Zhang, J.Y., et al., Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice. World J Gastroenterol, 2015. 21(14): p. 4195-209.
Zhang, C.B., et al., Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-κB signaling pathway. Experimental and Therapeutic Medicine, 2015. 9(6): p. 2114-2120.
Yu, J., et al., Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression. Toxicol Lett, 2015. 238(3): p. 11-19.
Sobue, S., et al., Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents. Mol Cell Biochem, 2015. 403(1-2): p. 231-41.
Lee, P.C., et al., Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen-rich saline and N-acetylcysteine treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats. Hepatol Res, 2015. 45(5): p. 578-88.
Tan, Y.C., et al., Hydrogen-rich saline attenuates postoperative liver failure after major hepatectomy in rats. Clin Res Hepatol Gastroenterol, 2014. 38(3): p. 337-45.
Matsuno, N., et al., Beneficial effects of hydrogen gas on porcine liver reperfusion injury with use of total vascular exclusion and active venous bypass. Transplant Proc, 2014. 46(4): p. 1104-6.
Liu, Y., et al., Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release. BMC Gastroenterol, 2014. 14: p. 12.
Koyama, Y., et al., Effects of oral intake of hydrogen water on liver fibrogenesis in mice. Hepatol Res, 2014. 44(6): p. 663-677.
Xu, X.F. and J. Zhang, Saturated hydrogen saline attenuates endotoxin-induced acute liver dysfunction in rats. Physiol Res, 2013. 62(4): p. 395-403.
Xia, C., et al., Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B. Clin Transl Sci, 2013. 6(5): p. 372-5.
Wang, W., et al., Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning. Journal of Emergency Medicine, 2013. 44(1): p. 107-15.
Liu, G.D., et al., Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells. Int J Ophthalmol, 2013. 6(3): p. 280-5.
Xiang, L., et al., Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine. World Journal of Gastroenterology, 2012. 18(37): p. 5197-5204.
Nishimura, N., et al., Pectin and high-amylose maize starch increase caecal hydrogen production and relieve hepatic ischaemia-reperfusion injury in rats. Br J Nutr, 2012. 107(4): p. 485-92.
Sun, H., et al., The protective role of hydrogen-rich saline in experimental liver injury in mice. Journal of Hepatology, 2011. 54(3): p. 471-80.
Shen, M.H., et al., Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning. Medical Hypotheses, 2010. 75(2): p. 235-237.
Liu, Q., et al., Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice. Liver International, 2010. 30(7): p. 958-968.
Tsai, C.F., et al., Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol, 2009. 47(8): p. 2031-6.
Park, S.K., et al., Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats. Biomed Res, 2009. 30(5): p. 263-9.
Kajiya, M., et al., Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Biochem Biophys Res Commun, 2009. 386(2): p. 316-21.
Itoh, T., et al., Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun, 2009. 389(4): p. 651-6.
Gharib, B., et al., Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. C R Acad Sci III, 2001. 324(8): p. 719-724.
Human Studies
Zhu, Q., et al., Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. Sci Rep, 2018. 8(1): p. 8051.
Nishimaki, K., et al., Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment. Curr Alzheimer Res, 2018. 15(5): p. 482-492.
Nakayama, M., et al., Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study. Sci Rep, 2018. 8(1): p. 254.
Ostojic, Sergej M., et al. “28-days Hydrogen-rich Water Supplementation Affects Exercise Capacity in Mid-age Overweight Women: 2942 Board# 225 June 1 3.” Medicine & Science in Sports & Exercise 50.5S (2018): 728-729.
Yang, Q., et al., Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy. Mol Clin Oncol, 2017. 7(5): p. 891-896.
Trivic, T., et al., Drinking hydrogen-rich water for 4 weeks positively affects serum antioxidant enzymes in healthy men: a pilot study. Current Topics in Nutraceutical Research, 2017. 15(1): p. 45-48.
Sun, Y.P. and L. Sun, Selective protective effect of hydrogen water on free radical injury of athletes after high-intensity exercise. Biomedical Research on Trace Elements, 2017. 28(10): p. 4558-4561.
Shibayama, Y., et al., Hydrogen-rich Water Modulates Redox Status Repeated Three Consecutive Days Of Strenuous Exercise (3298 Board# 203 June 2). Medicine & Science in Sports & Exercise, 2017. 49(5s): p. 941.
Ono, H., et al., Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection. J Stroke Cerebrovasc Dis, 2017.
Nishimaki, K., et al., Effects of molecular hydrogen assessed by an animal model and a randomized clinical study on mild cognitive impairment. Curr Alzheimer Res, 2017.
Mizuno, K., et al., Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life. Med Gas Res, 2017. 7(4): p. 247-255.
Korovljev, D., et al., Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women. Ir J Med Sci, 2017.
Katsumata, Y., et al., The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction- First Pilot Study in Humans. Circ J, 2017.
A. Ponte, A., et al., Effects of hydrogen rich water on prolonged intermittent exercise. J Sports Med Phys Fitness, 2017.
Shimminju, Effects of H2-Rich Water Consumption on Oxidative Stress, PBMC Profiles and Their Transcriptome: A Randomized, Double-blind, Controlled Study (Doctoral dissertation,). 2018.
Qian, L.R. and J.L. Shen, Successful treatment with hydrogen rich water in a case of chronic graft-versus-host-disease. Med Gas Res, 2016. 6(3): p. 177-179.
Maeda, K., et al., Improvement of the fraction of human mercaptalbumin on hemodialysis treatment using hydrogen-dissolved hemodialysis fluid: a prospective observational study. Renal Replacement Therapy, 2016. 2(1): p. 42.
Kawamura, T., et al., Effects of hydrogen bathing on exercise-induced oxidative stress and delayed-onset muscle soreness. Jpn J Phys Fitness Sports Med,, 2016. 65(3): p. 297-305.
Drid, P., et al., Molecular Hydrogen Affected Post-Exercise Recovery in Judo Athletes: 3820 Board# 259 June 4, 9: 30 AM-11: 00 AM.”. Medicine and science in sports and exercise, 2016. 48(5): p. 1071.
Tanikawa, R., et al., Relationship between Exhaled Hydrogen and Human Neutrophil Function in the Japanese General Population. Hirosaki Medical Journal, 2015. 65: p. 138-146.
Tamasawa, A., et al., Hydrogen gas production is associated with reduced interleukin-1beta mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients. Eur J Pharmacol, 2015. 762: p. 96-101.
Ishibashi, T., et al., Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases. Mol Med Rep, 2015. 12(2): p. 2757-64.
Azuma, T., et al., Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study. Antioxidants 4(3): p. 513-522.
Takeuchi, S., et al., Effects of intravenous infusion of hydrogen-rich fluid combined with intra-cisternal infusion of magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial. BMC Neurol, 2014. 14(1): p. 176.
Sakai, T., et al., Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function. Vasc Health Risk Manag, 2014. 10: p. 591-7.
Ostojic, S.M., et al., Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries. Postgrad Med, 2014. 126(5): p. 187-95.
Ostojic, S.M. and M.D. Stojanovic, Hydrogen-rich water affected blood alkalinity in physically active men. Res Sports Med, 2014. 22(1): p. 49-60.
Ishibashi, T., et al., Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: A randomized, double-blind, placebo-controlled pilot study. Int Immunopharmacol, 2014. 21(2): p. 468-473.
Yoritaka, A., et al., Pilot study of H(2) therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial. Movement Disorders, 2013.
Xia, C., et al., Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B. Clin Transl Sci, 2013. 6(5): p. 372-5.
Terawaki, H., et al., Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity. Medical Gas Research, 2013. 3(1): p. 14.
Song, G., et al., Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. Journal of Lipid Research, 2013. 54(7): p. 1884-93.
Shin, M.H., et al., Atomic Hydrogen Surrounded by Water Molecules, H(H2O)m, Modulates Basal and UV-Induced Gene Expressions in Human Skin In Vivo. PLoS One, 2013. 8(4): p. e61696.
Nagatani, K., et al., Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies. Med Gas Res, 2013. 3: p. 13.
Matsumoto, S., T. Ueda, and H. Kakizaki, Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome. Urology, 2013. 81(2): p. 226-30.
Li, Q., et al., Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro. Med Gas Res, 2013. 3(1): p. 20.
Drid, P., et al., Hydrogen-Rich Water in Judo Training. . Psycho-Physiological, Spiritual and Ethical Aspects), 2013: p. 129.
Ono, H., et al., Hydrogen (H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers. Medical Gas Research, 2012. 2(1): p. 14.
Ono, H., et al., A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level. Medical Gas Research, 2012. 2(1): p. 21.
Ishibashi, T., et al., Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study. Medical Gas Research, 2012. 2(1): p. 27.
Aoki, K., et al., Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Medical Gas Research, 2012. 2(1): p. 12.
Ostojić, S.M., et al., Drinks with alkaline negative oxidative reduction potential improve exercise performance in physically active men and women: Double-blind, randomized, placebo-controlled, cross-over trial of efficacy and safety. Serbian journal of sports sciences, 2011. 5(1-4): p. 83-89.
Kang, K.-M., et al., Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Medical Gas Research, 2011. 1: p. 11.
Ito, M., et al., Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. Medical Gas Research, 2011. 1(1): p. 24.
Nakayama, M., et al., A novel bioactive haemodialysis system using dissolved dihydrogen (H-2) produced by water electrolysis: a clinical trial. Nephrology Dialysis Transplantation, 2010. 25(9): p. 3026-3033.
Nakao, A., et al., Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome-An Open Label Pilot Study. Journal of Clinical Biochemistry and Nutrition, 2010. 46(2): p. 140-149.
Huang, K.C., et al., Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic haemodialysis. Nephrology Dialysis Transplantation, 2010. 25(8): p. 2730-2737.
Nakayama, M., et al., Biological Effects of Electrolyzed Water in Hemodialysis. Nephron Clinical Practice, 2009. 112(1): p. C9-C15.
Koyama K, T.Y., Saihara Y, Ando D, Goto Y, Katayama A, Effect of hydrogen saturated alkaline electrolyzed water on urinary oxidative stress markers after an acute exercise: A randomized controlled trial. Anti-aging Med, 2008. 4: p. 117-122.
Kajiyama, S., et al., Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research, 2008. 28: p. 137–143.
Yang, E.J., et al., A Clinical Trial of Orally Administered Alkaline Reduced Water. 대한의생명과학회지, 2007. 13(2): p. 83-89.
Bittner, A.C., et al., Intra-Individual Ergonomics (I2E): Performance Effects of Ultra-Negative-Ion Water. Proceedings of the Human Factors and Ergonomics Society Annual Meeting SAGE Journals, 2007. 55(26): p. 1617-1621.
Yeung, L.K., et al., Effect of electrolyzed reduced water hemodialysis on peripheral lymphocyte intracellular cytokine expression. Nephrology Dialysis Transplantation, 2006. 21: p. 204-204.
Lu, K.C., et al., Electrolyzed reduced water attenuates hemodialysis-induced mononuclear cells apoptosis in end-stage renal disease patients. Nephrology Dialysis Transplantation, 2006. 21: p. 200-201.
Huang, K.C., et al., Electrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients. Kidney Int, 2006. 70(2): p. 391-8.
Hiraoka, A., et al., Effects of drinking a water product with anti-oxidant activities in vitro on the blood levels of biomarker substances for the oxidative stress. Journal of Health Science, 2006. 52(6): p. 817-820.
Lee, K.J., et al., Effect of electrolyzed-reduced water: in vivo and in vitro examination and clinical trials, in The 3rd Asia Pacific Conference on Evidence-Based Medicine. 2004: Hong Kong.
Fujiyama, Y. and T. Kitahora, Alkaline electrolytic water (alkali ions water) for drinking water in medicine. Mizu no Tokusei to Atarashii Riyo Gijutsu, Enu-Ti-Esu, Tokyo, 2004: p. 348-457.
Huang, K.C., et al., Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water. Kidney Int, 2003. 64(2): p. 704-14.
Tashiro, H., et al., Clinical evaluation of alkali-ionized water for chronic diarrhea-placebo-controlled double blind study. Digestion & Absorption, 2000. 23: p. 52-56.