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Science of Hyperoxic Hypoxic Paradox
The most powerful anti-aging, regenerative & restorative trigger known to man.....

The Hyperoxic-Hypoxic Paradox

At our facility, we utilize the Hyperoxic-Hypoxic Paradox (HHP) protocol that in numerous studies has been shown to activate the body’s natural regenerative and restorative processes better than anything currently known to man.  The HHP is a result of 15+ years of research performed by Dr. Shai Efrati and the Sagol Center for Hyperbaric Medicine and Research in Israel.

In a standard 90-minute HBOT session, individuals alternate between breathing pure oxygen through a mask for 20 minutes and then remove the mask for a 5 - minute break, breathing the chamber’s normal/ambient air supply. This cycle is repeated throughout the session.

​The shift from breathing high oxygen through the mask (hyperoxia) for 20 minutes and then removing the mask for 5 minutes and breathing normal air oxygen levels, creates a signal at the cellular level similar to that of a low-oxygen environment (hypoxia), but without the risks of true hypoxia.

Extensive research has shown that HHP influences pathways related to tissue repair, vascular recovery, inflammation regulation, and cellular support.

​Documented effects include an 800% increase in stem cell production, a 25–30% increase in telomere length, a 30% reduction in senescent (“zombie”) cells, and measurable improvements in mitochondrial function and density.

​Additional findings point to modulation of cell signaling molecules and growth factors such as HIF-1, Sirtuins, MMP, VEGF, and BDNF.  which are associated with circulation and regeneration.

In summary: The HHP uses controlled oxygen exposure to stimulate regenerative and adaptive responses that support cellular communication, vascular health, and overall wellness.

Shai Efrati explains the miraculous benefits of the
Hyperoxic-Hypoxic Paradox protocol

Shai Efrati explains the increase of stem cell production through the Hyperoxic-Hypoxic Paradox protocol.

Learn More About Hyperbaric Oxygen Therapy

Learn more about how hyperbaric oxygen therapy works and who may benefit →

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